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Brc1cnc(nc1)C
Pyrimidine, 5-bromo-2-methyl-
CCCP1(=O)OP(=O)(CCC)OP(=O)(O1)CCC
1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide
CC1(C)OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C
2,2'-Bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-
O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]
Tris(dibenzylideneacetone)dipalladium
C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(c(c1)C)N1CCN(C1=[Ru](=Cc1ccccc1)(Cl)Cl)c1c(C)cc(cc1C)C
Ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-

Pyridine, 3-chloro-2-fluoro-

Clc1cccnc1F Request for Quotation
Chemical Name: Pyridine, 3-chloro-2-fluoro-
CAS Number: 1480-64-4
Product Number: AG003J6Y(AGN-PC-0KKP3E)
Synonyms:
MDL No:
Molecular Formula: C5H3ClFN
Molecular Weight: 131.5354

Identification/Properties

Properties
MP:
274°C
BP:
162.2°C at 760 mmHg
Storage:
Inert atmosphere;2-8℃;
Form:
Liquid
Refractive Index:
1.5030
Computed Properties
Molecular Weight:
131.534g/mol
XLogP3:
1.6
Hydrogen Bond Donor Count:
0
Hydrogen Bond Acceptor Count:
2
Rotatable Bond Count:
0
Exact Mass:
130.994g/mol
Monoisotopic Mass:
130.994g/mol
Topological Polar Surface Area:
12.9A^2
Heavy Atom Count:
8
Formal Charge:
0
Complexity:
78.8
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

Safety Information

NMR Spectrum

Other Analytical Data

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Chemical Structure


3-Chloro-2-fluoropyridine is a valuable chemical compound widely utilized in organic synthesis for its unique properties and reactivity. Its application in chemical synthesis is particularly noteworthy in the following ways:1. **Building block in pharmaceutical synthesis**: 3-Chloro-2-fluoropyridine serves as a versatile building block in the pharmaceutical industry. Its fluorine and chlorine substituents make it a valuable intermediate in the synthesis of various biologically active compounds, especially pharmaceuticals. These compounds often exhibit enhanced bioavailability, potency, and metabolic stability due to the presence of fluorine and chlorine atoms, making 3-Chloro-2-fluoropyridine an essential precursor in drug discovery and development.2. **Cross-coupling reactions**: The presence of reactive sites in 3-Chloro-2-fluoropyridine makes it an ideal substrate for cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig, and Heck reactions. These types of reactions enable the formation of complex molecular structures, allowing for the efficient synthesis of pharmaceuticals, agrochemicals, and materials with tailored properties.3. **Functional group manipulation**: The halogen substituents in 3-Chloro-2-fluoropyridine can be selectively modified to introduce specific functional groups, allowing for the customization of molecular structures. This flexibility is crucial in organic synthesis, where precise control over chemical transformations is essential to target specific properties or activities in the final products.Overall, the versatility and reactivity of 3-Chloro-2-fluoropyridine make it a valuable tool in chemical synthesis, enabling the construction of complex molecules with diverse applications in pharmaceuticals, materials science, and agrochemicals.