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Brc1cnc(nc1)C
Pyrimidine, 5-bromo-2-methyl-
CCCP1(=O)OP(=O)(CCC)OP(=O)(O1)CCC
1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide
CC1(C)OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C
2,2'-Bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-
O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]
Tris(dibenzylideneacetone)dipalladium
C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(c(c1)C)N1CCN(C1=[Ru](=Cc1ccccc1)(Cl)Cl)c1c(C)cc(cc1C)C
Ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-

Pyridine, 2-bromo-6-(trifluoromethyl)-

Brc1cccc(n1)C(F)(F)F Request for Quotation
Chemical Name: Pyridine, 2-bromo-6-(trifluoromethyl)-
CAS Number: 189278-27-1
Product Number: AG002I6C(AGN-PC-0KL1YT)
Synonyms:
MDL No: MFCD00153087
Molecular Formula: C6H3BrF3N
Molecular Weight: 225.9939

Identification/Properties

Properties
MP:
48-52 °C
BP:
170.7°C at 760 mmHg
Storage:
Inert atmosphere;2-8℃;
Form:
Solid
Computed Properties
Molecular Weight:
225.996g/mol
XLogP3:
2.8
Hydrogen Bond Donor Count:
0
Hydrogen Bond Acceptor Count:
4
Rotatable Bond Count:
0
Exact Mass:
224.94g/mol
Monoisotopic Mass:
224.94g/mol
Topological Polar Surface Area:
12.9A^2
Heavy Atom Count:
11
Formal Charge:
0
Complexity:
136
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

Safety Information

NMR Spectrum

Other Analytical Data

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Chemical Structure


2-Bromo-6-(trifluoromethyl)pyridine is a versatile compound widely used in chemical synthesis. Its unique molecular structure, featuring a bromine atom and a trifluoromethyl group on a pyridine ring, imparts distinct reactivity and functionality in various organic reactions. This compound is commonly employed as a building block in the synthesis of pharmaceuticals, agrochemicals, and materials due to its ability to introduce both bromine and trifluoromethyl functionalities into target molecules. In organic transformations, 2-Bromo-6-(trifluoromethyl)pyridine serves as an important electrophilic source of bromine and trifluoromethyl groups, allowing chemists to selectively introduce these moieties into specific positions of organic substrates. Its use in transition metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Kumada coupling, enables the construction of complex molecular structures with high efficiency and precision. Additionally, the presence of a trifluoromethyl group enhances the lipophilicity and pharmacokinetic properties of bioactive compounds, making it a valuable tool in medicinal chemistry for designing novel drug candidates. In summary, 2-Bromo-6-(trifluoromethyl)pyridine plays a crucial role in modern chemical synthesis by facilitating the construction of diverse molecular architectures with enhanced functionalities and properties.