Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester


Chemical Name: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester
CAS Number: 111652-20-1
Product Number: AG0079E0(AGN-PC-0L59YX)
Synonyms:
MDL No:
Molecular Formula: C11H21NO4
Molecular Weight: 231.2887

Identification/Properties


Computed Properties
Molecular Weight:
231.292g/mol
XLogP3:
1.8
Hydrogen Bond Donor Count:
1
Hydrogen Bond Acceptor Count:
4
Rotatable Bond Count:
6
Exact Mass:
231.147g/mol
Monoisotopic Mass:
231.147g/mol
Topological Polar Surface Area:
64.6A^2
Heavy Atom Count:
16
Formal Charge:
0
Complexity:
260
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

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Chemical Structure



Boc-Gly-OtBu is a commonly used protected amino acid derivative in chemical synthesis. Its application lies in facilitating the formation of peptide bonds during the assembly of peptides and proteins. By incorporating Boc-Gly-OtBu into the synthesis of peptides, chemists are able to mask the amino group of glycine, thereby protecting it from premature reactions while allowing for selective deprotection and subsequent coupling reactions. This enables precise control over the peptide sequence and ensures the desired end product is obtained with high purity and yield. Furthermore, the Boc protecting group can be readily removed under mild conditions, making Boc-Gly-OtBu a versatile tool in peptide chemistry. Its efficient utilization in solid-phase peptide synthesis and solution-phase peptide coupling reactions makes it an invaluable component in the tool kit of synthetic chemists striving to construct complex peptides and proteins with precision and efficiency.