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Brc1cnc(nc1)C
Pyrimidine, 5-bromo-2-methyl-
CCCP1(=O)OP(=O)(CCC)OP(=O)(O1)CCC
1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide
CC1(C)OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C
2,2'-Bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-
O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]
Tris(dibenzylideneacetone)dipalladium
C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(c(c1)C)N1CCN(C1=[Ru](=Cc1ccccc1)(Cl)Cl)c1c(C)cc(cc1C)C
Ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-

L-Tyrosinamide,N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

CC(CC(C(=O)NC(C(=O)NC(C(=O)Nc1ccc2c(c1)oc(=O)cc2C)Cc1ccc(cc1)O)C(C)C)NC(=O)C(NC(=O)CCC(=O)O)CC(C)C)C Request for Quotation
Chemical Name: L-Tyrosinamide,N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
CAS Number: 94367-21-2
Product Number: AG01E5Y8(AGN-PC-0W4062)
Synonyms:
MDL No:
Molecular Formula: C40H53N5O10
Molecular Weight: 763.8763

Identification/Properties

Computed Properties
Molecular Weight:
763.889g/mol
XLogP3:
4.3
Hydrogen Bond Donor Count:
7
Hydrogen Bond Acceptor Count:
10
Rotatable Bond Count:
19
Exact Mass:
763.379g/mol
Monoisotopic Mass:
763.379g/mol
Topological Polar Surface Area:
229A^2
Heavy Atom Count:
55
Formal Charge:
0
Complexity:
1410
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
4
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

Safety Information

NMR Spectrum

Other Analytical Data

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Chemical Structure


Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic substrate commonly utilized in chemical synthesis for studying enzyme activity. This peptide substrate consists of five amino acids - L-leucine, L-valine, L-tyrosine, and 7-amino-4-methylcoumarin (AMC) attached to an N-succinyl moiety at the N-terminus. The succinyl group enhances water solubility and stability of the substrate. In chemical synthesis, Suc-Leu-Leu-Val-Tyr-AMC is often employed as a substrate to determine the activity of enzymes such as proteases and peptidases. When these enzymes cleave the peptide bond between the tyrosine and AMC, the fluorophore AMC is liberated, resulting in a measurable fluorescence signal. This fluorescence signal can be monitored over time to quantify enzyme activity, assess enzyme kinetics, screen for enzyme inhibitors, and study enzyme mechanisms.Overall, Suc-Leu-Leu-Val-Tyr-AMC serves as a versatile tool in chemical synthesis for investigating enzyme functions and developing new pharmaceuticals targeting these enzymes.