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Brc1cnc(nc1)C
Pyrimidine, 5-bromo-2-methyl-
CCCP1(=O)OP(=O)(CCC)OP(=O)(O1)CCC
1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide
CC1(C)OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C
2,2'-Bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-
O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]
Tris(dibenzylideneacetone)dipalladium
C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(c(c1)C)N1CCN(C1=[Ru](=Cc1ccccc1)(Cl)Cl)c1c(C)cc(cc1C)C
Ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-

UNC 0646

COc1cc2c(NC3CCN(CC3)C3CCCCC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C Request for Quotation
Chemical Name: UNC 0646
CAS Number: 1320288-17-2
Product Number: AG00102F(AGN-PC-0WAH0H)
Synonyms:
MDL No:
Molecular Formula: C36H59N7O2
Molecular Weight: 621.8994

Identification/Properties

Computed Properties
Molecular Weight:
621.915g/mol
XLogP3:
6.9
Hydrogen Bond Donor Count:
1
Hydrogen Bond Acceptor Count:
9
Rotatable Bond Count:
11
Exact Mass:
621.473g/mol
Monoisotopic Mass:
621.473g/mol
Topological Polar Surface Area:
69.2A^2
Heavy Atom Count:
45
Formal Charge:
0
Complexity:
845
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

Safety Information

NMR Spectrum

Other Analytical Data

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Chemical Structure


UNC0646 is a potent and selective inhibitor of the histone lysine methyltransferase (HMT) G9a, also known as EHMT2. G9a is a crucial enzyme involved in catalyzing the methylation of histone H3 at lysine 9, leading to the silencing of gene expression. By inhibiting G9a, UNC0646 can modulate the methylation status of histone proteins, thereby influencing gene transcription and epigenetic regulation.In chemical synthesis, UNC0646 can be utilized as a powerful tool for investigating the role of histone methylation in various biological processes. Its specificity towards G9a makes it a valuable compound for studying the impact of G9a-mediated histone methylation on gene expression patterns and cellular functions. Researchers can use UNC0646 to explore the epigenetic mechanisms underlying disease states or to uncover potential therapeutic targets in conditions where dysregulated histone methylation is implicated.Furthermore, UNC0646's ability to selectively inhibit G9a provides a means to manipulate histone methylation levels in a controlled manner, offering insights into the molecular pathways regulated by this epigenetic modification. By incorporating UNC0646 into chemical synthesis workflows, scientists can elucidate the functional consequences of histone methylation changes and advance our understanding of epigenetic processes in health and disease.