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The chemists at Angene excel in chemical process research and development, custom synthesis, and scale-up of key pharmaceutical intermediates and APIs. Synthetic route optimization is a key core competency of the chemistry team, which is composed of highly creative and experienced research chemists.
-Development of in-process controls,processing hold points, key process parameters, purification by crystallization, final form selection/control, and robust isolation, drying,and milling procedures
-Modern research facility, with ready access to kilo labs and pilot plant, allowing manufacture from mg to hundreds of tons scale with rapid turnaround
-Identification of key opportunities for decreasing manufacturing costs while increasing robustness
-Chemistry team stays with the project from early laboratory development through late-stage plant manufacture to ensure program continuity
-Highly experienced and proactive project management group; weekly project updates provided; final campaign/research summary reports provided upon completion of program.
-Synthesis and purification of analytical reference standards
-Large scale chromatography