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Brc1cnc(nc1)C
Pyrimidine, 5-bromo-2-methyl-
CCCP1(=O)OP(=O)(CCC)OP(=O)(O1)CCC
1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide
CC1(C)OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C
2,2'-Bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-
O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]
Tris(dibenzylideneacetone)dipalladium
C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(c(c1)C)N1CCN(C1=[Ru](=Cc1ccccc1)(Cl)Cl)c1c(C)cc(cc1C)C
Ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-

(2-chloro-6-fluoro-3-hydroxyphenyl)boronic acid

OB(c1c(F)ccc(c1Cl)O)O Request for Quotation
Chemical Name: (2-chloro-6-fluoro-3-hydroxyphenyl)boronic acid
CAS Number: 957121-07-2
Product Number: AG006BL3(AGN-PC-078TDF)
Synonyms:
MDL No:
Molecular Formula: C6H5BClFO3
Molecular Weight: 190.3645

Identification/Properties

Properties
Storage:
2-8℃;
Form:
Solid
Computed Properties
Molecular Weight:
190.361g/mol
Hydrogen Bond Donor Count:
3
Hydrogen Bond Acceptor Count:
4
Rotatable Bond Count:
1
Exact Mass:
190g/mol
Monoisotopic Mass:
190g/mol
Topological Polar Surface Area:
60.7A^2
Heavy Atom Count:
12
Formal Charge:
0
Complexity:
160
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

Safety Information

GHS Pictogram:
Signal Word:
Warning
UN#:
N/A
Hazard Statements:
H302-H315-H319-H335
Precautionary Statements:
P261-P280-P301+P312-P302+P352-P305+P351+P338
Class:
N/A
Packing Group:
N/A

NMR Spectrum

Other Analytical Data

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Chemical Structure


2-Chloro-6-fluoro-3-hydroxyphenylboronic acid is a versatile compound commonly utilized in chemical synthesis for a wide range of applications. This specific boronic acid derivative is valued for its ability to act as a key building block in the construction of complex organic molecules. It serves as a crucial intermediate in various synthetic pathways, facilitating the formation of important pharmaceuticals, agrochemicals, and materials.In chemical synthesis, 2-Chloro-6-fluoro-3-hydroxyphenylboronic acid is often employed in Suzuki-Miyaura cross-coupling reactions. This palladium-catalyzed coupling process enables the selective formation of carbon-carbon bonds between an aryl halide and an organoboron compound, with the boronic acid serving as the nucleophilic partner. This reaction has found widespread use in medicinal chemistry, allowing for the efficient assembly of structurally diverse compounds with tailored properties.Additionally, 2-Chloro-6-fluoro-3-hydroxyphenylboronic acid can participate in other types of transformations, such as halogenation, arylation, and borylation reactions. Its strategic incorporation into a synthetic route can enable the introduction of specific functional groups or structural motifs critical for the desired molecular target. The unique combination of chlorine, fluorine, and hydroxyl groups in this compound imparts distinct reactivity and selectivity, making it a valuable tool in the hands of synthetic chemists striving to design and create novel compounds with enhanced properties.