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Brc1cnc(nc1)C
Pyrimidine, 5-bromo-2-methyl-
CCCP1(=O)OP(=O)(CCC)OP(=O)(O1)CCC
1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide
CC1(C)OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C
2,2'-Bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-
O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]
Tris(dibenzylideneacetone)dipalladium
C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(c(c1)C)N1CCN(C1=[Ru](=Cc1ccccc1)(Cl)Cl)c1c(C)cc(cc1C)C
Ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-

6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride

Clc1ncc(cc1C(F)(F)F)S(=O)(=O)Cl Request for Quotation
Chemical Name: 6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride
CAS Number: 928324-59-8
Product Number: AG00H5CC(AGN-PC-0J0Y1T)
Synonyms:
MDL No:
Molecular Formula: C6H2Cl2F3NO2S
Molecular Weight: 280.0518

Identification/Properties

Computed Properties
Molecular Weight:
280.042g/mol
XLogP3:
2.7
Hydrogen Bond Donor Count:
0
Hydrogen Bond Acceptor Count:
6
Rotatable Bond Count:
1
Exact Mass:
278.914g/mol
Monoisotopic Mass:
278.914g/mol
Topological Polar Surface Area:
55.4A^2
Heavy Atom Count:
15
Formal Charge:
0
Complexity:
326
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

Safety Information

GHS Pictogram:
Signal Word:
Danger
UN#:
3261
Hazard Statements:
H302-H314
Precautionary Statements:
P280-P305+P351+P338-P310
Class:
8
Packing Group:
Ⅱ

NMR Spectrum

Other Analytical Data

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Chemical Structure


6-Chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride is an essential reagent in chemical synthesis, particularly in the field of organic chemistry. This compound serves as a highly versatile building block for the construction of various complex molecules and intermediates. Its unique structure containing a sulfonyl chloride functional group coupled with a chloro and trifluoromethyl substituent on a pyridine ring offers a wide range of reactivity and selectivity in synthetic transformations.In chemical synthesis, 6-Chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride is commonly employed as a valuable electrophilic reagent for introducing the sulfonyl chloride moiety into organic molecules. This reactive intermediate can participate in various nucleophilic substitution reactions, such as SNAr (nucleophilic aromatic substitution) reactions, enabling the selective functionalization of aromatic systems. Additionally, the trifluoromethyl group enhances the reactivity and stability of the molecule, making it an ideal reagent for challenging synthetic transformations.Furthermore, the presence of the chloro group allows for further derivatization of the molecule through cross-coupling reactions or other functional group manipulations. This versatility makes 6-Chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride a valuable tool in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals where precise control over molecular design and functionality is crucial.