Phosphoramidous acid, bis(1-methylethyl)-, dimethyl ester


Chemical Name: Phosphoramidous acid, bis(1-methylethyl)-, dimethyl ester
CAS Number: 122194-07-4
Product Number: AG0016XA(AGN-PC-0LNUPD)
Synonyms:
MDL No:
Molecular Formula: C8H20NO2P
Molecular Weight: 193.2237

Identification/Properties


Computed Properties
Molecular Weight:
193.227g/mol
XLogP3:
1.9
Hydrogen Bond Donor Count:
0
Hydrogen Bond Acceptor Count:
3
Rotatable Bond Count:
5
Exact Mass:
193.123g/mol
Monoisotopic Mass:
193.123g/mol
Topological Polar Surface Area:
21.7A^2
Heavy Atom Count:
12
Formal Charge:
0
Complexity:
108
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
0
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

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NMR Spectrum


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Chemical Structure



Dimethyl N,N-diisopropylphosphoramidite is a versatile reagent commonly used in chemical synthesis, especially in the field of organic chemistry. This compound is known for its ability to act as a phosphitylating agent, where it can transfer a phosphite functional group to various nucleophiles. In particular, Dimethyl N,N-diisopropylphosphoramidite is frequently employed in the synthesis of nucleosides and oligonucleotides, crucial components in the production of DNA and RNA molecules. Furthermore, this reagent plays a pivotal role in solid-phase synthesis strategies, enabling the efficient assembly of complex chemical structures with high purity and yield. Its selective reactivity and compatibility with a wide range of substrates make Dimethyl N,N-diisopropylphosphoramidite an essential tool for researchers and chemists working in the field of molecular biology and drug discovery.