Chemical Name: | L-Histidine, N,1-bis[(9H-fluoren-9-ylmethoxy)carbonyl]- |
CAS Number: | 98929-98-7 |
Product Number: | AG0066L6(AGN-PC-0OP0S8) |
Synonyms: | |
MDL No: | |
Molecular Formula: | C36H29N3O6 |
Molecular Weight: | 599.6320 |
Fmoc-His(Fmoc)-OH is a valuable building block widely used in chemical synthesis and peptide chemistry. It serves as a protected form of histidine, a naturally occurring amino acid commonly found in proteins and peptides. In the context of chemical synthesis, Fmoc-His(Fmoc)-OH plays a crucial role in peptide chain elongation and modification.One of the key applications of Fmoc-His(Fmoc)-OH is in solid-phase peptide synthesis, where it is utilized as a starting material for the assembly of complex peptide sequences. By incorporating Fmoc-His(Fmoc)-OH into the peptide chain, chemists can introduce the specific amino acid histidine at desired positions within the sequence. The Fmoc protection group ensures that the histidine residue remains unreactive during the synthesis process, allowing for selective deprotection and subsequent coupling steps.Moreover, Fmoc-His(Fmoc)-OH can also be used in the functionalization and modification of peptides. By strategically incorporating this building block into a peptide sequence, chemists can introduce histidine residues with preserved reactivity for further chemical manipulations. This flexibility enables the creation of novel peptide derivatives with tailored properties and functions.Overall, Fmoc-His(Fmoc)-OH is a versatile tool in chemical synthesis, offering precise control over the incorporation of histidine residues in peptides and enabling the synthesis of diverse peptide structures for various research and therapeutic applications.