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Brc1cnc(nc1)C
Pyrimidine, 5-bromo-2-methyl-
CCCP1(=O)OP(=O)(CCC)OP(=O)(O1)CCC
1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide
CC1(C)OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C
2,2'-Bi-1,3,2-dioxaborolane, 4,4,4',4',5,5,5',5'-octamethyl-
O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.[Pd].[Pd]
Tris(dibenzylideneacetone)dipalladium
C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.Cc1cc(C)c(c(c1)C)N1CCN(C1=[Ru](=Cc1ccccc1)(Cl)Cl)c1c(C)cc(cc1C)C
Ruthenium,[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-

L-Phenylalanine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(trifluoromethyl)-

O=C(N[C@H](C(=O)O)Cc1cccc(c1)C(F)(F)F)OCC1c2ccccc2c2c1cccc2 Request for Quotation
Chemical Name: L-Phenylalanine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(trifluoromethyl)-
CAS Number: 205526-27-8
Product Number: AG002A4V(AGN-PC-0QVD97)
Synonyms:
MDL No:
Molecular Formula: C25H20F3NO4
Molecular Weight: 455.4258

Identification/Properties

Properties
MP:
147-157°C
BP:
611.2±55.0°C at 760 mmHg
Storage:
Keep in dry area;2-8℃;
Form:
Solid
Computed Properties
Molecular Weight:
455.433g/mol
XLogP3:
5.5
Hydrogen Bond Donor Count:
2
Hydrogen Bond Acceptor Count:
7
Rotatable Bond Count:
7
Exact Mass:
455.134g/mol
Monoisotopic Mass:
455.134g/mol
Topological Polar Surface Area:
75.6A^2
Heavy Atom Count:
33
Formal Charge:
0
Complexity:
678
Isotope Atom Count:
0
Defined Atom Stereocenter Count:
1
Undefined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Covalently-Bonded Unit Count:
1
Compound Is Canonicalized:
Yes

Safety Information

GHS Pictogram:
Signal Word:
Warning
UN#:
N/A
Hazard Statements:
H315-H319-H335
Precautionary Statements:
P261-P305+P351+P338
Class:
N/A
Packing Group:
N/A

NMR Spectrum

Other Analytical Data

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Chemical Structure


Fmoc-Phe(3-CF3)-OH, also known as Fmoc-protected 3-trifluoromethylphenylalanine, is a versatile building block widely used in chemical synthesis. This compound is commonly employed in the solid-phase peptide synthesis (SPPS) of peptides due to its ability to selectively protect the amino group of phenylalanine residues.In peptide synthesis, Fmoc-Phe(3-CF3)-OH is utilized as a key component for the controlled stepwise assembly of peptides on a solid support. By incorporating this Fmoc-protected amino acid into the peptide sequence, it allows for efficient and selective deprotection under mild conditions, enabling the desired peptide chain elongation without undesired side reactions.Furthermore, the trifluoromethyl group on the phenylalanine side chain confers unique properties to the resulting peptides, such as altered molecular interactions and enhanced biological activities. This makes Fmoc-Phe(3-CF3)-OH a valuable tool for the design and synthesis of peptide mimetics, bioactive peptides, and pharmaceutical compounds with improved properties.Overall, Fmoc-Phe(3-CF3)-OH plays a pivotal role in peptide chemistry by facilitating the precise construction of complex peptide sequences and enabling the exploration of novel peptide-based therapeutics and materials.